RapamycinFungusV1, Main, Exploration, bibRecord, 000551

Metformin influences drug sensitivity in pancreatic cancer cells.

Identifieur interne : 000551 ( Main/Exploration ); précédent : 000550; suivant : 000552

Metformin influences drug sensitivity in pancreatic cancer cells.

Auteurs : Saverio Candido [Italie] ; Stephen L. Abrams [États-Unis] ; Linda Steelman [États-Unis] ; Kvin Lertpiriyapong [États-Unis] ; Alberto M. Martelli [Italie] ; Lucio Cocco [Italie] ; Stefano Ratti [Italie] ; Matilde Y. Follo [Italie] ; Ramiro M. Murata [États-Unis] ; Pedro L. Rosalen [Brésil] ; Paolo Lombardi [Italie] ; Giuseppe Montalto [Italie] ; Melchiorre Cervello [Italie] ; Agnieszka Gizak [Pologne] ; Dariusz Rakus [Pologne] ; Pann-Gill Suh [Corée du Sud] ; Massimo Libra [Italie] ; James A. Mccubrey [États-Unis]

Source :

Advances in biological regulation [ 2212-4934 ] ; 2018.

RBID : pubmed:29482945

Descripteurs français

KwdFr :
- Animaux (MeSH), Carcinome du canal pancréatique (traitement médicamenteux), Diabète de type 2 (MeSH), Humains (MeSH), Interactions médicamenteuses (MeSH), Metformine (usage thérapeutique), Sirolimus (usage thérapeutique), Transduction du signal (effets des médicaments et des substances chimiques), Tumeurs du pancréas (traitement médicamenteux).
MESH :
- effets des médicaments et des substances chimiques : Transduction du signal.
- traitement médicamenteux : Carcinome du canal pancréatique, Tumeurs du pancréas.
- usage thérapeutique : Metformine, Sirolimus.
- Animaux, Diabète de type 2, Humains, Interactions médicamenteuses.

English descriptors

KwdEn :
- Animals (MeSH), Carcinoma, Pancreatic Ductal (drug therapy), Diabetes Mellitus, Type 2 (MeSH), Drug Interactions (MeSH), Humans (MeSH), Metformin (therapeutic use), Pancreatic Neoplasms (drug therapy), Signal Transduction (drug effects), Sirolimus (therapeutic use).
MESH :
- chemical , therapeutic use : Metformin, Sirolimus.
- drug effects : Signal Transduction.
- drug therapy : Carcinoma, Pancreatic Ductal, Pancreatic Neoplasms.
- Animals, Diabetes Mellitus, Type 2, Drug Interactions, Humans.

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive, highly metastatic malignancy and accounts for 85% of pancreatic cancers. PDAC patients have poor prognosis with a five-year survival of only 5-10% after diagnosis and treatment. Pancreatic cancer has been associated with type II diabetes as the frequency of recently diagnosed diabetics that develop pancreatic cancer within a 10-year period of initial diagnosis of diabetes in increased in comparison to non-diabetic patients. Metformin is a very frequently prescribed drug used to treat type II diabetes. Metformin acts in part by stimulating AMP-kinase (AMPK) and results in the suppression of mTORC1 activity and the induction of autophagy. In the following studies, we have examined the effects of metformin in the presence of various chemotherapeutic drugs, signal transduction inhibitors and natural products on the growth of three different PDAC lines. Metformin, by itself, was not effective at suppressing growth of the pancreatic cancer cell lines at concentration less than 1000 nM, however, in certain PDAC lines, a suboptimal dose of metformin (250 nM) potentiated the effects of various chemotherapeutic drugs used to treat pancreatic cancer (e.g., gemcitabine, cisplatin, 5-fluorouracil) and other cancer types (e.g., doxorubicin, docetaxel). Furthermore, metformin could increase anti-proliferative effects of mTORC1 and PI3K/mTOR inhibitors as well as natural products such as berberine and the anti-malarial drug chloroquine in certain PDAC lines. Thus, metformin can enhance the effects of certain drugs and signal transduction inhibitors which are used to treat pancreatic and various other cancers.

DOI: 10.1016/j.jbior.2018.02.002
PubMed: 29482945

Affiliations:

Links toward previous steps (curation, corpus...)

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Le document en format XML

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<author><name sortKey="Lombardi, Paolo" sort="Lombardi, Paolo" uniqKey="Lombardi P" first="Paolo" last="Lombardi">Paolo Lombardi</name>
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<author><name sortKey="Cervello, Melchiorre" sort="Cervello, Melchiorre" uniqKey="Cervello M" first="Melchiorre" last="Cervello">Melchiorre Cervello</name>
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<author><name sortKey="Gizak, Agnieszka" sort="Gizak, Agnieszka" uniqKey="Gizak A" first="Agnieszka" last="Gizak">Agnieszka Gizak</name>
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<author><name sortKey="Rakus, Dariusz" sort="Rakus, Dariusz" uniqKey="Rakus D" first="Dariusz" last="Rakus">Dariusz Rakus</name>
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<author><name sortKey="Suh, Pann Gill" sort="Suh, Pann Gill" uniqKey="Suh P" first="Pann-Gill" last="Suh">Pann-Gill Suh</name>
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<author><name sortKey="Libra, Massimo" sort="Libra, Massimo" uniqKey="Libra M" first="Massimo" last="Libra">Massimo Libra</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Metformin influences drug sensitivity in pancreatic cancer cells.</title>
<author><name sortKey="Candido, Saverio" sort="Candido, Saverio" uniqKey="Candido S" first="Saverio" last="Candido">Saverio Candido</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical and Biotechnological Sciences - Pathology & Oncology Section, University of Catania, Catania, Italy.</nlm:affiliation>
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<author><name sortKey="Abrams, Stephen L" sort="Abrams, Stephen L" uniqKey="Abrams S" first="Stephen L" last="Abrams">Stephen L. Abrams</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology & Immunology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology & Immunology, Brody School of Medicine, East Carolina University, Greenville, NC 27834</wicri:regionArea>
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<author><name sortKey="Steelman, Linda" sort="Steelman, Linda" uniqKey="Steelman L" first="Linda" last="Steelman">Linda Steelman</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology & Immunology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology & Immunology, Brody School of Medicine, East Carolina University, Greenville, NC 27834</wicri:regionArea>
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<author><name sortKey="Lertpiriyapong, Kvin" sort="Lertpiriyapong, Kvin" uniqKey="Lertpiriyapong K" first="Kvin" last="Lertpiriyapong">Kvin Lertpiriyapong</name>
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<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Martelli, Alberto M" sort="Martelli, Alberto M" uniqKey="Martelli A" first="Alberto M" last="Martelli">Alberto M. Martelli</name>
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<author><name sortKey="Cocco, Lucio" sort="Cocco, Lucio" uniqKey="Cocco L" first="Lucio" last="Cocco">Lucio Cocco</name>
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<wicri:regionArea>Department of Biomedical and Neuromotor Sciences, Università di Bologna, Bologna</wicri:regionArea>
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<author><name sortKey="Ratti, Stefano" sort="Ratti, Stefano" uniqKey="Ratti S" first="Stefano" last="Ratti">Stefano Ratti</name>
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<author><name sortKey="Follo, Matilde Y" sort="Follo, Matilde Y" uniqKey="Follo M" first="Matilde Y" last="Follo">Matilde Y. Follo</name>
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<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Biomedical and Neuromotor Sciences, Università di Bologna, Bologna</wicri:regionArea>
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<author><name sortKey="Murata, Ramiro M" sort="Murata, Ramiro M" uniqKey="Murata R" first="Ramiro M" last="Murata">Ramiro M. Murata</name>
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<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Rosalen, Pedro L" sort="Rosalen, Pedro L" uniqKey="Rosalen P" first="Pedro L" last="Rosalen">Pedro L. Rosalen</name>
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<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Department of Physiological Sciences, Piracicaba Dental School, State University of Campinas, Piracicaba</wicri:regionArea>
<wicri:noRegion>Piracicaba</wicri:noRegion>
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<author><name sortKey="Lombardi, Paolo" sort="Lombardi, Paolo" uniqKey="Lombardi P" first="Paolo" last="Lombardi">Paolo Lombardi</name>
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<country xml:lang="fr">Italie</country>
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<author><name sortKey="Montalto, Giuseppe" sort="Montalto, Giuseppe" uniqKey="Montalto G" first="Giuseppe" last="Montalto">Giuseppe Montalto</name>
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<country xml:lang="fr">Italie</country>
<wicri:regionArea>Biomedical Department of Internal Medicine and Specialties, University of Palermo, Palermo, Italy; Consiglio Nazionale delle Ricerche, Istituto di Biomedicina e Immunologia Molecolare "Alberto Monroy", Palermo</wicri:regionArea>
<wicri:noRegion>Palermo</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cervello, Melchiorre" sort="Cervello, Melchiorre" uniqKey="Cervello M" first="Melchiorre" last="Cervello">Melchiorre Cervello</name>
<affiliation wicri:level="1"><nlm:affiliation>Consiglio Nazionale delle Ricerche, Istituto di Biomedicina e Immunologia Molecolare "Alberto Monroy", Palermo, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Consiglio Nazionale delle Ricerche, Istituto di Biomedicina e Immunologia Molecolare "Alberto Monroy", Palermo</wicri:regionArea>
<wicri:noRegion>Palermo</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gizak, Agnieszka" sort="Gizak, Agnieszka" uniqKey="Gizak A" first="Agnieszka" last="Gizak">Agnieszka Gizak</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Physiology and Neurobiology, Wroclaw University, Wroclaw, Poland.</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Molecular Physiology and Neurobiology, Wroclaw University, Wroclaw</wicri:regionArea>
<wicri:noRegion>Wroclaw</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rakus, Dariusz" sort="Rakus, Dariusz" uniqKey="Rakus D" first="Dariusz" last="Rakus">Dariusz Rakus</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Physiology and Neurobiology, Wroclaw University, Wroclaw, Poland.</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Molecular Physiology and Neurobiology, Wroclaw University, Wroclaw</wicri:regionArea>
<wicri:noRegion>Wroclaw</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Suh, Pann Gill" sort="Suh, Pann Gill" uniqKey="Suh P" first="Pann-Gill" last="Suh">Pann-Gill Suh</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Life Sciences, Ulsan National Institute of Science and Technology (UNIST), Ulsan, Republic of Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
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<wicri:noRegion>Ulsan</wicri:noRegion>
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<author><name sortKey="Libra, Massimo" sort="Libra, Massimo" uniqKey="Libra M" first="Massimo" last="Libra">Massimo Libra</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical and Biotechnological Sciences - Pathology & Oncology Section, University of Catania, Catania, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Biomedical and Biotechnological Sciences - Pathology & Oncology Section, University of Catania, Catania</wicri:regionArea>
<wicri:noRegion>Catania</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mccubrey, James A" sort="Mccubrey, James A" uniqKey="Mccubrey J" first="James A" last="Mccubrey">James A. Mccubrey</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology & Immunology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA. Electronic address: mccubreyj@ecu.edu.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology & Immunology, Brody School of Medicine, East Carolina University, Greenville, NC 27834</wicri:regionArea>
<placeName><region type="state">Caroline du Nord</region>
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<series><title level="j">Advances in biological regulation</title>
<idno type="eISSN">2212-4934</idno>
<imprint><date when="2018" type="published">2018</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term>
<term>Carcinoma, Pancreatic Ductal (drug therapy)</term>
<term>Diabetes Mellitus, Type 2 (MeSH)</term>
<term>Drug Interactions (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Metformin (therapeutic use)</term>
<term>Pancreatic Neoplasms (drug therapy)</term>
<term>Signal Transduction (drug effects)</term>
<term>Sirolimus (therapeutic use)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term>
<term>Carcinome du canal pancréatique (traitement médicamenteux)</term>
<term>Diabète de type 2 (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Interactions médicamenteuses (MeSH)</term>
<term>Metformine (usage thérapeutique)</term>
<term>Sirolimus (usage thérapeutique)</term>
<term>Transduction du signal (effets des médicaments et des substances chimiques)</term>
<term>Tumeurs du pancréas (traitement médicamenteux)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Metformin</term>
<term>Sirolimus</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Signal Transduction</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Carcinoma, Pancreatic Ductal</term>
<term>Pancreatic Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Transduction du signal</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Carcinome du canal pancréatique</term>
<term>Tumeurs du pancréas</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Metformine</term>
<term>Sirolimus</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Diabetes Mellitus, Type 2</term>
<term>Drug Interactions</term>
<term>Humans</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Diabète de type 2</term>
<term>Humains</term>
<term>Interactions médicamenteuses</term>
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<front><div type="abstract" xml:lang="en">Pancreatic ductal adenocarcinoma (PDAC) is an aggressive, highly metastatic malignancy and accounts for 85% of pancreatic cancers. PDAC patients have poor prognosis with a five-year survival of only 5-10% after diagnosis and treatment. Pancreatic cancer has been associated with type II diabetes as the frequency of recently diagnosed diabetics that develop pancreatic cancer within a 10-year period of initial diagnosis of diabetes in increased in comparison to non-diabetic patients. Metformin is a very frequently prescribed drug used to treat type II diabetes. Metformin acts in part by stimulating AMP-kinase (AMPK) and results in the suppression of mTORC1 activity and the induction of autophagy. In the following studies, we have examined the effects of metformin in the presence of various chemotherapeutic drugs, signal transduction inhibitors and natural products on the growth of three different PDAC lines. Metformin, by itself, was not effective at suppressing growth of the pancreatic cancer cell lines at concentration less than 1000 nM, however, in certain PDAC lines, a suboptimal dose of metformin (250 nM) potentiated the effects of various chemotherapeutic drugs used to treat pancreatic cancer (e.g., gemcitabine, cisplatin, 5-fluorouracil) and other cancer types (e.g., doxorubicin, docetaxel). Furthermore, metformin could increase anti-proliferative effects of mTORC1 and PI3K/mTOR inhibitors as well as natural products such as berberine and the anti-malarial drug chloroquine in certain PDAC lines. Thus, metformin can enhance the effects of certain drugs and signal transduction inhibitors which are used to treat pancreatic and various other cancers.</div>
</front>
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<DateCompleted><Year>2019</Year>
<Month>10</Month>
<Day>10</Day>
</DateCompleted>
<DateRevised><Year>2019</Year>
<Month>10</Month>
<Day>10</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">2212-4934</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>68</Volume>
<PubDate><Year>2018</Year>
<Month>05</Month>
</PubDate>
</JournalIssue>
<Title>Advances in biological regulation</Title>
<ISOAbbreviation>Adv Biol Regul</ISOAbbreviation>
</Journal>
<ArticleTitle>Metformin influences drug sensitivity in pancreatic cancer cells.</ArticleTitle>
<Pagination><MedlinePgn>13-30</MedlinePgn>
</Pagination>
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<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jbior.2018.02.002</ELocationID>
<Abstract><AbstractText>Pancreatic ductal adenocarcinoma (PDAC) is an aggressive, highly metastatic malignancy and accounts for 85% of pancreatic cancers. PDAC patients have poor prognosis with a five-year survival of only 5-10% after diagnosis and treatment. Pancreatic cancer has been associated with type II diabetes as the frequency of recently diagnosed diabetics that develop pancreatic cancer within a 10-year period of initial diagnosis of diabetes in increased in comparison to non-diabetic patients. Metformin is a very frequently prescribed drug used to treat type II diabetes. Metformin acts in part by stimulating AMP-kinase (AMPK) and results in the suppression of mTORC1 activity and the induction of autophagy. In the following studies, we have examined the effects of metformin in the presence of various chemotherapeutic drugs, signal transduction inhibitors and natural products on the growth of three different PDAC lines. Metformin, by itself, was not effective at suppressing growth of the pancreatic cancer cell lines at concentration less than 1000 nM, however, in certain PDAC lines, a suboptimal dose of metformin (250 nM) potentiated the effects of various chemotherapeutic drugs used to treat pancreatic cancer (e.g., gemcitabine, cisplatin, 5-fluorouracil) and other cancer types (e.g., doxorubicin, docetaxel). Furthermore, metformin could increase anti-proliferative effects of mTORC1 and PI3K/mTOR inhibitors as well as natural products such as berberine and the anti-malarial drug chloroquine in certain PDAC lines. Thus, metformin can enhance the effects of certain drugs and signal transduction inhibitors which are used to treat pancreatic and various other cancers.</AbstractText>
<CopyrightInformation>Copyright © 2018 Elsevier Ltd. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Candido</LastName>
<ForeName>Saverio</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Department of Biomedical and Biotechnological Sciences - Pathology & Oncology Section, University of Catania, Catania, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Abrams</LastName>
<ForeName>Stephen L</ForeName>
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<AffiliationInfo><Affiliation>Department of Microbiology & Immunology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Steelman</LastName>
<ForeName>Linda</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology & Immunology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lertpiriyapong</LastName>
<ForeName>Kvin</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Department of Comparative Medicine, Brody School of Medicine at East Carolina University, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Martelli</LastName>
<ForeName>Alberto M</ForeName>
<Initials>AM</Initials>
<AffiliationInfo><Affiliation>Department of Biomedical and Neuromotor Sciences, Università di Bologna, Bologna, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cocco</LastName>
<ForeName>Lucio</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Department of Biomedical and Neuromotor Sciences, Università di Bologna, Bologna, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ratti</LastName>
<ForeName>Stefano</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Department of Biomedical and Neuromotor Sciences, Università di Bologna, Bologna, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Follo</LastName>
<ForeName>Matilde Y</ForeName>
<Initials>MY</Initials>
<AffiliationInfo><Affiliation>Department of Biomedical and Neuromotor Sciences, Università di Bologna, Bologna, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Murata</LastName>
<ForeName>Ramiro M</ForeName>
<Initials>RM</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology & Immunology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA; Department of Foundational Sciences, School of Dental Medicine, East Carolina University, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Rosalen</LastName>
<ForeName>Pedro L</ForeName>
<Initials>PL</Initials>
<AffiliationInfo><Affiliation>Department of Physiological Sciences, Piracicaba Dental School, State University of Campinas, Piracicaba, Brazil.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lombardi</LastName>
<ForeName>Paolo</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Naxospharma, Via Giuseppe Di Vittorio 70, Novate Milanese 20026, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Montalto</LastName>
<ForeName>Giuseppe</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Biomedical Department of Internal Medicine and Specialties, University of Palermo, Palermo, Italy; Consiglio Nazionale delle Ricerche, Istituto di Biomedicina e Immunologia Molecolare "Alberto Monroy", Palermo, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cervello</LastName>
<ForeName>Melchiorre</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Consiglio Nazionale delle Ricerche, Istituto di Biomedicina e Immunologia Molecolare "Alberto Monroy", Palermo, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gizak</LastName>
<ForeName>Agnieszka</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Molecular Physiology and Neurobiology, Wroclaw University, Wroclaw, Poland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Rakus</LastName>
<ForeName>Dariusz</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Department of Molecular Physiology and Neurobiology, Wroclaw University, Wroclaw, Poland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Suh</LastName>
<ForeName>Pann-Gill</ForeName>
<Initials>PG</Initials>
<AffiliationInfo><Affiliation>School of Life Sciences, Ulsan National Institute of Science and Technology (UNIST), Ulsan, Republic of Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Libra</LastName>
<ForeName>Massimo</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Biomedical and Biotechnological Sciences - Pathology & Oncology Section, University of Catania, Catania, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>McCubrey</LastName>
<ForeName>James A</ForeName>
<Initials>JA</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology & Immunology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA. Electronic address: mccubreyj@ecu.edu.</Affiliation>
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<Language>eng</Language>
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<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
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<ArticleDate DateType="Electronic"><Year>2018</Year>
<Month>02</Month>
<Day>12</Day>
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<MedlineTA>Adv Biol Regul</MedlineTA>
<NlmUniqueID>101572336</NlmUniqueID>
<ISSNLinking>2212-4926</ISSNLinking>
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<Chemical><RegistryNumber>W36ZG6FT64</RegistryNumber>
<NameOfSubstance UI="D020123">Sirolimus</NameOfSubstance>
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<SupplMeshList><SupplMeshName Type="Disease" UI="C562463">Pancreatic Carcinoma</SupplMeshName>
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<QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName>
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<MeshHeading><DescriptorName UI="D020123" MajorTopicYN="N">Sirolimus</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
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<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">AMPK</Keyword>
<Keyword MajorTopicYN="Y">Metformin</Keyword>
<Keyword MajorTopicYN="Y">Rapamycin</Keyword>
<Keyword MajorTopicYN="Y">Signal transduction inhibitors</Keyword>
<Keyword MajorTopicYN="Y">mTORC1</Keyword>
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Metformin influences drug sensitivity in pancreatic cancer cells.

Metformin influences drug sensitivity in pancreatic cancer cells.

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